Like other drugs and substances such as caffeine, patients can develop a cbd tolerance over time. This article will discuss tolerance building for THC and CBD… Much like other substances we ingest in our everyday lives, CBD users can build up a tolerance to the cannabinoid compound over time.
Can you build tolerance to CBD?
Is it possible for patients to build up a tolerance to their medical cannabis medication? The answer is both yes and no. The reason being is that tolerance profiles are different for THC and CBD, the two main active components of medical cannabis. While frequent use of medical cannabis will lead to a higher tolerance to THC, the same isn’t necessarily true for CBD.
The aim of this article is to answer some of the following questions for patients:
- Will I build a tolerance for medical cannabis?
- Will I need to take more and more over time to help me manage pain?
- Will I become dependent on large doses of cannabis?
What is Tolerance?
Developing tolerance means having to take increasingly higher doses to achieve the same effects as initially experienced. Please note that building tolerance isn’t to be confused with physical addiction or dependence. People who frequently drink coffee will find that they must drink more to feel the same effects as when they first started drinking. But why does the body build a tolerance to substances in the first place?
Your body’s primary function is keeping itself in a state of homeostasis, or cellular balance. When a foreign substance is introduced, whether it’s drugs, food or even water, the body processes it and immediately tries to restore itself to homeostasis. This explains why frequent consumers of alcohol have built a high tolerance over time because the body gets better at adapting itself to regulating the chemical imbalance to the best of its ability.
Will patients develop CBD tolerance to Medical Cannabis?
Before we answer this question, it’s first important to separate and distinguish medical cannabis into two main active components: THC and CBD, as tolerance-building works differently for each.
THC or tetrahydrocannabinol is the psychoactive ingredient that is responsible for users feeling “high.” CBD or Cannabidiol is regarded as the medicinal element that has been shown to alleviate the symptoms of anxiety, chronic pain, depression and nerve pain. Unlike THC, CBD does not cause any intoxicating effects. However, THC does demonstrate clear health benefits for patients suffering from pain, low appetite, insomnia and PTSD.
Will patients develop a tolerance to THC?
Yes, patients can develop a tolerance to THC. Similar to other drugs and chemicals like caffeine, continual and heavy THC use will result in tolerance-building.
When THC is consumed, it binds to CB1 receptors that primarily located in the brain. After heavy THC usage, these CB1 receptors become more resistant and begin to downregulate the effects of THC to maintain balance. In other words, the more THC that you consume, the better and more efficient your body becomes at managing it.
Will patients need to take more THC to feel the same effects?
Yes, as recreational users will confirm, frequent use of THC will result in having to take more THC to attain the same effects. Over time, CB1 receptors become less sensitive to THC. So when you introduce this cannabinoid into your system, only a portion of it triggers those receptors and causes a reaction. This happens due to CB1 receptors adapting to your cannabis consumption. High levels of THC in the body become the new norm, which means you need to start taking more substantial doses to feel the same effects.
How can patients reduce THC tolerance?
The key to reducing THC tolerance is taking periodic breaks. By taking breaks, you allow your receptors time to recover and replenish. Studies have shown that receptors start to rejuvenate in as little as two days. Taking regular breaks every few weeks will help maintain your tolerance at a moderate level. Patients who wish to reset their THC tolerances back to zero should abstain from cannabis for approximately four weeks.
Will patients experience withdrawal from THC?
Ultimately, withdrawal symptoms depend on the length and frequency of use. While many users will not feel withdrawal effects, long-term users with heavy use may experience withdrawal symptoms, such as:
- Mild insomnia
- Reduced appetite
- Cannabis cravings
- Mood changes
- Headaches, sweating, chills
The duration of withdrawal symptoms is approximately two weeks, with most symptoms peaking within the first week.
Will patients build a tolerance to CBD?
No. The good news is, CBD doesn’t seem to create a CBD tolerance in regular users. This is because CBD and THC don’t bind to CB1 receptors in the same way. As a result, when CBD binds to these receptors, they don’t become desensitized.
In a 2011 study published by Mateus Machodo Bergamaschi et al. found that “CBD administration did not induce side effects across a wide range of dosages, including acute and chronic dose regimens, and tolerance to CBD did not develop.“
Some researchers even suggest that CBD creates “reverse CBD tolerance,” meaning that patients need to take less and less over time. So for medical cannabis patients that rely mainly on things like CBD oil, or CBD-dominant cannabis strains, CBD tolerance isn’t something to worry about.
The Final Word
Medical cannabis helps thousands of people. But, while it is very safe, it can also create a tolerance to THC. For patients who rely on THC-high products for relief and wish to keep their tolerance in check, it is recommended to take periodic breaks every few weeks.
No matter what you use medical cannabis for, it’s important to remember that it does change the way that your body works. Understanding those mechanisms is crucial to safe and effective cannabis consumption.
CBD Tolerance: Can you build a tolerance to CBD?
Much like other substances we ingest in our everyday lives, CBD users can build up a tolerance to the cannabinoid compound over time.
So, just as you might need more coffee to get the same energy boost after drinking it every day for a week, you might need to take more CBD to experience the effects to which you are accustomed.
This doesn’t mean that CBD isn’t working anymore or that you’re doing something wrong – it’s just a natural process that happens when our bodies get used to something.
If you are experiencing lessened effects of CBD, or are interested in adjusting your body’s tolerance level, check out this guide covering everything there is to know about CBD tolerance.
The science behind CBD
Cannabidiol (CBD) is one of the most prevalent cannabinoids found in cannabis or hemp plants. Also known as a phytocannabinoid, CBD interacts with our bodies through endocannabinoid system receptors. These receptors are found throughout our entire body, including our brain, organs, and central nervous system.
According to a study published by the National Center for Biotechnology Information (NCBI), CBD activates several receptor types throughout our body: CB1 receptors found in the central nervous system and brain, CB2 receptors found in the peripheral nervous system, enzymes involved with metabolism, muscle and joint function, fertility, and more.
It’s worth noting that while the use of the more well-known cannabinoid THC (tetrahydrocannabinol) also interacts with our endocannabinoid receptors, it does so in a way that causes psychoactive effects or the “high” associated with marijuana use. On the other hand, CBD is non-psychoactive and won’t get you high.
Different types of tolerance
Tolerance can be classified into two different types: metabolic tolerance and functional tolerance.
Metabolic tolerance occurs when the human body loses efficiency in breaking down and metabolizing a substance. For example, if you’re drinking alcohol every day, your liver will eventually become less effective at metabolizing it, resulting in lower blood alcohol concentration.
Functional tolerance is when our body becomes less responsive to the effects of a substance. So, if you’re taking CBD every day, your body may eventually become less responsive to its effects, and you’ll need more of it to experience the same health benefits.
While both types of tolerances could be the culprit for reduced CBD efficacy, it’s more likely that functional tolerance is the culprit for reduced CBD effects because CBD hasn’t been shown to decrease the efficiency of our metabolic and receptor systems. In other words, our bodies just get used to having it in our system – we need more of it because we simply become less sensitive to its presence.
How can CBD tolerance increase?
CBD tolerance is unavoidable if you engage in regular use of the cannabinoid regularly whether to relieve sore muscles and joints after regular workouts or to help with more serious issues like chronic pain or epilepsy. Just like with any other substance, our bodies will get used to it and eventually require more of the cannabinoid to experience the same effects.
This is because when CBD enters our system, it interacts with enzymes in our liver that are responsible for metabolizing drugs. CBD is a “fat-soluble” compound, which means it’s metabolized differently than other substances like alcohol or caffeine. When we consume CBD, it’s stored in our fatty tissues and liver before being slowly released into our system.
This extended-release is why CBD tends to have long-lasting effects, but it also means that our body has more time to build up a tolerance to the cannabinoid.
Factors that indicate a tolerance to CBD
If you are unsure whether the lessened effects of the CBD you consume for health and wellness are a result of higher tolerance or inferior quality hemp CBD oil extracts, here are some factors to take into account:
- You find that you need to use more CBD products than before to achieve the desired effects
- CBD effects aren’t as strong as they used to be
- It takes longer for CBD effects to kick in
While it’s not uncommon to develop a higher tolerance to CBD over time, it’s important to ensure that the products you’re using are high quality and potent. Inferior quality CBD products might not be giving you the effects you want because they contain a lower concentration of cannabinoids or have not been extracted using the best method.
How to fix a tolerance to CBD
If you’re interested in reducing your tolerance to CBD, there are some things you can do. Changing how you use CBD products is a great place to start, especially if you’ve been using it in the same form for a while.
For example, if you usually take edibles or other CBD gummies , try using a topical CBD product or vape oil instead. You can also switch between full-spectrum, broad-spectrum, and pure CBD isolate products.
If you’re using CBD for medical purposes and have developed a tolerance to it, talk to your doctor about other treatment options. They might be able to recommend a different dosage or form of CBD that would be more effective for you.
It’s also important to take a break from CBD every now and then, especially if you’re using it daily. This will give your body a chance to reset and could help reduce your tolerance to the cannabinoid.
Will I have high CBD tolerance if I have a high THC tolerance?
If you consume marijuana regularly, you might be wondering if your tolerance to THC will affect your tolerance to CBD.
The answer is – not necessarily. While they are both cannabinoids found in cannabis, they interact with our bodies differently. This means that you could have a high tolerance to THC but not CBD, or vice versa.
Furthermore, even though both marijuana and hemp are members of the Cannabis sativa plant family, the CBD content in THC-rich marijuana cannabis plants is much lower than the CBD concentration found in the hemp cannabis plants used to make CBD products in the UK. Therefore, it’s unlikely that your THC tolerance would significantly affect your CBD tolerance.
Why do I feel weird when stopping CBD to reset my tolerance?
Withdrawal symptoms after stopping CBD are infrequent, but they can happen. These side effects are usually mild and include headaches, fatigue, and irritability. Often, this can indicate a CBD dependence, which is different from tolerance to CBD.
A dependence on CBD can occur after long-term use when your body has relied on the cannabinoid for so long that it has grown accustomed to using it, just as it would to caffeine. This means that you will experience mild withdrawal symptoms if you stop using CBD completely, even if you have a high tolerance to it.
Fortunately, it’s easy to reset your sensitivity to CBD and avoid dependence on it if you use the cannabinoid regularly. Simply stop using the cannabinoid for a few days or weeks, then start again with a lower dose than before. You could also swap between full-spectrum CBD oil tinctures and isolate products, as these contain a varying amount of CBD and other hemp compounds.
Does high Endocannabinoid System (ECS) tolerance affect CBD use?
Technically, you can develop a tolerance to any substance that interacts with the endocannabinoid system (ECS). This is because your body naturally produces endocannabinoids – endogenous cannabinoids – which bind to cannabinoid receptors and help regulate various bodily functions.
If you use CBD or THC on a regular basis, your body might start producing less endocannabinoids. This is because it assumes that you’re already getting enough cannabinoids from external sources, so it doesn’t need to produce as many of its own.
Over time, this can decrease sensitivity to cannabinoids, which means you will need to consume more of them to experience the same effects. However, it’s worth noting that this is different from developing a tolerance to CBD or THC specifically.
Natural tolerance factors
Some people may feel like they need more CBD than others to experience the same effects, even if they haven’t been using cannabidiol for a long enough period of time to build a tolerance.
This natural tolerance has less to do with CBD consumption and more with your body’s ability to absorb it. Factors like age, metabolism, weight, height, hydration levels, and genetics are just some of the things that can affect how quickly you feel the effects of cannabidiol.
Time-specific tolerances can also be a factor. For example, you may feel cannabidiol’s effects more in the morning than at night because your body is naturally more receptive to cannabinoids when you first wake up. Or you may feel like you feel the effects more when you don’t eat before taking CBD, as food can also affect how quickly cannabidiol is absorbed into the bloodstream.
Don’t worry, CBD tolerance is normal
While you may feel frustrated that you need more and more CBD to experience the same effects, it’s important to remember that this is perfectly normal. In fact, it’s not just CBD – tolerance can occur with any type of medication or supplement, whether it’s over-the-counter or prescription medications.
The good news is that there are a few things you can do to avoid tolerance build-up, such as taking regular breaks from CBD or using a higher potency product. By understanding how CBD tolerance works, you can make sure you’re using the cannabinoid in the most effective way possible.
You can now buy CBD oil products by clicking here , or read our buyer’s guides to the best CBD oils and best CBD gummies in the UK.
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