CBD, a popular alternative treatment in treating inflammation, may worsen the side effects of the anti-inflammatory drug prednisone if used together. Studies have shown that CBD possesses potential therapeutic benefits that may help with some symptoms or conditions where prednisone is indicated. Learn more.
Does CBD Interact With Prednisone (Rayos)?
Information on risks & possible interactions between CBD & prednisone.
Prednisone (Rayos) is a common steroid medication used for inflammation and pain. It’s highly effective but comes with a long list of potential side effects. CBD is sometimes used as an alternative, and many take both of them together.
Is it safe to take CBD and prednisone together? What are the risks?
Learn about the potential interactions between these infamous anti-inflammatory substances.
Table of Contents
Does CBD Interact With Prednisone (Rayos)?
Due to the many side effects associated with prednisone, CBD may be a safer alternative.
CBD can inhibit the action of CYP3A4, a liver enzyme that metabolizes several kinds of drugs, including prednisone. Because of its inhibitory activity, it can cause the enzyme to slow down. This could cause the metabolism of prednisone to slow down as well, meaning prednisone would remain in the system for a longer time frame and more liable to cause more side effects.
CBD also interacts with many other kinds of drugs. These are divided into three main categories. They are:
1. Increased Effect (Agonistic Interaction)
This interaction happens when two substances have the same effects in the body due to both of them acting on the same receptors to push in the same direction.
Because CBD and prednisone share many of the same effects, the combination could potentially lead to side effects.
2. Slowed Elimination (Metabolic Competition)
All drugs need to be metabolized by the liver, including CBD.
A metabolic competitor refers to substances that require the same pathway for metabolism. This causes both compounds to compete for metabolism, leading to buildups and a slow breakdown of both compounds.
CBD and prednisone are both metabolized by CYP3A4 and may compete for metabolism, increasing the duration of effects of both substances.
Taking either CBD, prednisone, or both substances daily may lead to gradual buildups in the blood, causing harmful side effects to occur.
Other Names For Prednisone
Prednisone is sold under many different names. All share the same risk and potential interactions.
Other names for prednisone include:
Similar Medications: CBD & Immunosuppressants
Prednisone is classified as an immunosuppressant. CBD and immunosuppressants all share similar risks for interaction and side effects.
Here’s a list of similar medications that share an equal level of risk when combined with CBD:
- Azathioprine (Imuran)
- Mycophenolate Mofetil (Cellcept)
- Cyclosporine (Neoral, Sandimmune, Gengraf)
- Methotrexate (Rheumatrex)
- Leflunomide (Arava)
- Cyclophosphamide (Cytoxan)
- Chlorambucil (Leukeran)
- Nitrogen Mustard (Mustargen)
Is It Safe to Take CBD & Prednisone (Rayos) Together?
CBD and prednisone can be taken together safely, but the dose of both substances may need to be modified. Always ask your doctor about taking CBD if you have a prescription for prednisone.
Is CBD a Viable Alternative to Prednisone (Rayos)?
There is not much research about how effective CBD is in treating symptoms of inflammation and other conditions like the ones that prednisone treats, so it cannot be considered an adequate alternative to prednisone.
All available information shows CBD could treat inflammation, but its efficacy and potency are still being evaluated. It is best to consult your doctor first before deciding to switch to CBD.
What Is Prednisone (Rayos)?
Prednisone (Rayos) is a type of glucocorticoid. It was first discovered in 1955 by Schering Corporation under the brand name Meticorten and Delta-Cortef. It got its approval for use by the FDA in 2012.
Prednisone is a synthetic pregnane corticosteroid and a derivative of cortisone.
Prednisone is used in the treatment of asthma, COPD, rheumatologic diseases, neoplasia, etc. It can also treat high blood calcium due to cancer and adrenal insufficiency.
|Trade Name||Deltasone, Liquid Pred, Meticorten, Orasone, Rayos, Prednisone Intensol, Sterapred, Sterapred DS|
|CYP Metabolism||Cytochrome P450|
|Interaction With CBD||Metabolic competitor|
|Risk of Interaction||Moderate|
What Does Prednisone (Rayos) Do?
Prednisone is a synthetic steroid. This drug has anti-inflammatory and immunomodulating properties.
Prednisone is a prodrug that gets hydroxylated to an active metabolite form called Prednisolone. This form controls its glucocorticoid effects. This hydroxylation process may get impaired in liver disease.
Inflammation is the body’s natural response to injury or infection of any kind. The immune system works to contain and eliminate the pathogens that are causing the inflammation. It causes redness, swelling, raised temperature over the affected part, and pain. In chronic conditions such as arthritis, inflammations can cause constant pain and may decrease the functionality of the organs.
Prednisone decreases inflammation by suppressing the migration of the polymorphonuclear leukocytes and reversing the raised capillary permeability that happens in inflammation.
It also stops the multiple inflammatory genes activated in inflammatory diseases and suppresses the immune system by decreasing its activity and volume. It has antineoplastic effects, which it does by stopping glucose transport and inducing the death of immature lymphocytes.
Prednisone gets metabolized by the CYP450 enzymes in the liver, including the CYP3A4 enzyme.
What Are the Side Effects of Prednisone (Rayos)?
Common prednisone side effects include:
- Blurred vision
- Changes in behavior or mood
- Elevated blood pressure levels
- Elevated blood sugar levels
- Fluid retention
- Restlessness and inability to stay still (akathisia)
- Sleep problems
Serious side effects of prednisone are:
- Osteoporosis, bone loss, and fractures, osteonecrosis
- Increased risk of infection
- Cardiovascular problems like atherosclerosis, hypertension, etc
- Skin problems like impaired wound healing, striae, urticaria, allergic dermatitis, and others
- Abnormal fat deposits
- Diabetes Mellitus
- Gastric ulcer and GI bleeding
- Corticosteroid induced psychosis
Contraindications of Prednisone (Rayos)
Prednisone should not be taken in some conditions. They are:
- Untreated serious infections
- Known hypersensitivity to prednisone
- Administration of live or attenuated live vaccine
Some Important Points to Know About Prednisone (Rayos)
There are some points that you should know about before using this medication. These are:
A) Stopping Prednisone
This drug is similar to cortisol, a hormone produced by the adrenal glands that regulate many functions. If prednisone is used for a long time, say a few weeks to months, the adrenal glands will decrease their cortisol production.
If you stop taking this medication abruptly, your body may go into symptoms like prednisone withdrawal, so gradual tapering is needed. Some of the withdrawal symptoms of stopping prednisone consist of fatigue, joint pains, stiffening of muscles, and fever.
B) Prolonged Use of Prednisone
Prolonged use of this drug can cause several unwanted effects in the body. These include an increased risk of infection, osteoporosis, delayed wound healing, elevated intraocular pressure, glaucoma, cataracts, and reactivation of latent tuberculosis.
C) Monitoring the Patients
It is of great importance to monitor patients taking prednisone as it may cause hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing syndrome, hyperglycemia, and psychiatric disturbances.
D) Use In Various Diseases
Prednisone can be given in low doses for some chronic diseases, including liver diseases, hypertension, thyroid disorders, osteoporosis, kidney diseases, diabetes mellitus, and gastrointestinal disorders. However, caution is necessary. Patients receiving this medication should avoid chickenpox or measles-infected persons if unvaccinated.
E) Use In Pregnancy & Lactating Mothers
Prednisone can be dangerous in pregnancy as it can cause harm to the fetus. It also increases the risk of cleft palate. It is expressed in the milk in lactating mothers and may cause problems in the baby, so the lowest dose must be used.
Because of the many adverse effects of prednisone, more users are searching for natural alternatives like CBD to treat inflammations.
What Is CBD (Cannabidiol)?
Cannabidiol or CBD is the second most common compound extracted from the Cannabis sativa plant. It’s usually inhaled or taken orally. It does not cause intoxication and isn’t psychoactive, unlike some other cannabinoids.
Cannabidiol has been undergoing research for its role in treating inflammation, anxiety, cognition, movement disorders, and pain [1, 2]. Epidiolex, a drug containing cannabidiol, has been approved by the FDA for treating two epilepsy conditions.
Also, a 1:1 combination of CBD and tetrahydrocannabinol (THC), another cannabis extract, can treat spasticity in multiple sclerosis.
How Does CBD Work?
CBD can interact with the endocannabinoid system (ECS), a biological system containing endocannabinoids, a type of neurotransmitters. These endocannabinoids bind to the cannabinoid receptor proteins. The ECS is vital for conducting neural functions and balances cognitive processes, pain sensation, and mood.
There are two primary cannabinoid receptors, CB1 and CB2. CB1 receptors are present mainly in the brain and central nervous tissues.
CB2 receptors can be found in peripheral organs, especially the immune system. THC, cannabis’ main component, binds to CB1 directly and mediates its psychoactive properties.
However, CBD alters the action of the receptors that bind to the cannabinoids. CBD can interact with CB2 receptors, induce vasodilation, turn off the inflammatory reaction, and activate 5HT1A receptors that provide therapeutic relief in diabetic neuropathy. It also helps decrease oxidative stress and inflammation .
CBD is metabolized in the liver by cytochrome P450 enzymes such as CYP1A1, CYP1A2, CYP1A22, CYP1B1, CYP2B6, CYP2C19, CYP2D6, CYP3A4, and CYP3A5.
CBD is also a competitive inhibitor for these same enzymes. It can occupy sites of enzymatic activity and can displace its chemical competitors. Due to this, the enzymes of cytochrome P450 will be unable to metabolize other compounds.
Side Effects of CBD
There are some side effects of CBD that one should know. They are:
- Mouth dryness
- Decreased appetite
Key Takeaways: Is It Safe to Take Prednisone (Rayos) With CBD?
CBD is well-tolerated in the general population and has shown effectiveness in treating inflammations just as prednisone (Rayos) can. However, both these drugs can interact with each other and worsen each other’s effects. Consult your doctor first before using CBD.
Also, if you plan on using CBD, you need to taper prednisone gradually. Only when it is certain that the two drugs will not interact with each other can you start with CBD.
There’s ongoing research on CBD’s therapeutic effects, so perhaps we’ll find out more about its uses and interactions with time.
CBD Oil and Prednisone – August 2022
Does CBD interact with prednisone, and if so, are there risks that should cause concern?
Prednisone is a prescription drug used to provide relief for inflamed areas of the body. It is also indicated to treat conditions, such as inflammation (swelling), severe allergies, arthritis , asthma, eye or vision problems, blood or bone marrow problems, and stomach or bowel problems (1 ) .
Moreover, doctors prescribe prednisone to help patients with lupus, skin conditions, endocrine problems, kidney problems, ulcerative colitis, adrenal problems, and flare-ups of multiple sclerosis.
Prednisone is a corticosteroid, or a cortisone-like medicine or steroid. This drug works on the immune system to help relieve swelling, redness, itching, and allergic reactions.
However, this medicine may cause changes in mood or behavior for some patients. Symptoms to watch for include depression, trouble with sleeping , a false or unusual sense of well-being, mood swings, and personality changes while taking this medicine (2 ) .
Can CBD Be Taken With Prednisone?
Taking CBD along with prednisone could either decrease the effects of cannabidiol or increase the amount of prednisone entering the bloodstream.
Whenever one takes CBD or any medicine, it passes through the digestive system to the liver, where an enzymatic pathway, called the cytochrome P450 (CYP450) family of enzymes, metabolizes or breaks down the substance ingested.
Liver enzymes CYP450 process about 60% of all medications. One of these, CYP3A4, metabolizes prednisone to make it available to the body (3 ) .
Studies have demonstrated that CBD strongly inhibits the activity of CYP3A4 liver enzymes (4 ) .
Meanwhile, prednisone is a weak inducer of CYP3A4 (5 ) . Still, prednisone may increase how quickly the liver breaks down CBD when they are taken in combination.
In particular, the effects of taking CBD along with prednisone could either decrease the effects of cannabidiol or increase the amount of prednisone entering the bloodstream.
The increased prednisone concentration can amplify the drug’s many side effects and raise the risk of severe symptoms, such as dizziness or fainting, blurred vision, irregular or pounding heartbeat, increased thirst or urination, irritability, and unusual tiredness or weakness (6 ) .
Thus, medical experts advise those taking CBD and prednisone to be cautious with this combination (7 ) .
Can CBD Replace Prednisone?
N o study explicitly says CBD can be used in place of prednisone. However, studies have shown that CBD possesses many potential therapeutic benefits that may help with some symptoms or conditions for which prednisone is indicated.
Prednisone is sometimes prescribed for bone marrow problems , which is important for the health of blood cells . Meanwhile, studies have shown that CBD promotes the structural health of bones .
The effect of CBD on bones was also demonstrated by a 2015 study that investigated the properties of cannabidiol concerning bone-related conditions. Data showed that CBD led to an improvement in fracture healing (8 ) .
Like prednisone, CBD can help with skin conditions. A study published in the journal Trends in Pharmacological Sciences has suggested the existence of a functiona l endocannabinoid system (ECS) in the skin and implicated it in various biological processes (9 ) .
CBD impacts the TRPV-1 and GPR55 receptors (10 ) . Both receptors are found in the skin and play a role in pain signaling and inflammation.
CBD has also been shown to help with mood swings, depression, dizziness, and sleeping difficulty, which may be the side effects from taking prednisone.
A study published in the Journal of Psychopharmacology found that CBD may decrease anxiety levels in individuals with a social anxiety disorder (SAD).
Results indicated that, relative to placebo, CBD was associated with significantly decreased subjective anxiety (11 ) .
In another study, results showed that CBD could theoretically induce rapid-acting antidepressant-like effects and enhance neurotransmission (12 ) . Neurotransmission is the process of communication between nerve cells.
In a 2019 study published in The Permanente Journal , sleep and anxiety scores were measured in human subjects, and the findings showed that CBD could hold benefits for anxiety-related disorders (13 ) .
Meanwhile, CBD’s antiemetic properties, which prevent nausea and vomiting, are incredibly helpful.
A 2014 review from the European Journal of Pharmacology established the potential of cannabis to limit or prevent nausea and vomiting from a wide range of causes (14 ) .
More importantly, the powerful anti-inflammatory properties of CBD could help with some of the same disorders that prednisone treats.
CBD’s anti-inflammatory characteristics have been shown in several human and animal studies, like that of a 2014 study published in the Journal of Clinical Investigation and a 2012 research conducted by authors from the Department of Pathology, School of Veterinary Medicine in the University of São Paulo, Brazil (15 ) .
Other studies have demonstrated that the anti-inflammatory and immunosuppressive actions of CBD may be of use in treating rheumatoid arthritis and the associated pain (16 ) .
Meanwhile, research published in the Free Radical Biology & Medicine Journal by George Booz of the University of Mississippi Medical Center showed that CBD, which may interact with the endocannabinoid system, is a promising prototype for anti-inflammatory drug development (17 ) .
CBD “is generally well tolerated with a good safety profile,” the World Health Organization (WHO) states in a critical review (18 ) .
Still, it is not clear how much to take or how often a person should use it for any particular problem.
High doses of CBD may also interact with other medications, such as blood thinners, antidepressants, and immune suppressors (19 ) .
Thus, individuals should be cautious when supplementing their existing medications with CBD.
Do not take other pharmaceuticals unless they have been discussed with a medical professional.
More importantly, before using CBD as a remedy for specific symptoms or conditions, consult with a doctor experienced in cannabis use for advice.