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The largest bottle of CBD oil that Spruce offers contains 2,400mg of CBD. This is full-spectrum CBD oil, which is the maximum possible potency. Each high potency dropper full contains 80mg of CBD. There are no flavorings in it, which allows for the most CBD to fit in the 30ml bottle.

4. Avida Full Spectrum CBD Oil Tincture 500mg
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Light Spearmint flavor

No other flavor

Non-THC, Non-detected in drug test

Overview

Avida Extracts Full Spectrum CBD oil is the latest iteration of the brand’s advanced Avida CORE Spectrum technology. They use a proprietary full spectrum blend, resulting in the highest naturally occurring Phyto-cannabinoids and Terpenes with THC (<0.3) to support your health.

5. cbdMD CBD Oil Tincture Natural 1500mg
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Various delicious flavors to choose from

cbdMD uses MCT as its carrier oil so individuals who are allergic with coconuts should consider other brand options

Has vegan, organic, and gluten-free ingredients

Free shipping for this particular product within USA

World-class customer service team

Overview

cbdMD’s CBD oil tinctures are made using only CBD sourced from medical hemp and MCT oil as a carrier oil. Tinctures are offered in orange, mint, natural, and berry flavors. Safe for daily use, the oil tinctures are packaged with a built-in rubber dropper to adjust CBD dosage easily. The packaging is made to be easy to transport and discreet to use.

6. CBDistillery THC Free CBD Oil Tinctures
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60-Day Satisfaction Guarantee

Dropper is a bit shaky

Oil extracted from aerial plant parts of US grown industrial hemp

Sourced from non-GMO industrial hemp grown in the USA through natural farming practices

Overview

CBDistillery’s Isolate CBD Oil Tinctures harness the power of pure CBD. CBD Isolate Oil Tinctures include 0.0% THC. When you use CBDistillery CBD Isolate Oil Tinctures, you can be assured you’re using the highest quality CBD on the market.

7. NuLeaf Naturals 300mg Full Spectrum Hemp CBD Oil
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No other flavors

A bit pricey compared to competitors

Approximately 100 drops total

Overview

This is one of several concentrations from NuLeaf Naturals. As the lowest concentration, it is the company’s best option for those new to CBD oil. The product is lab-tested and fully organic. It is full-spectrum, so it contains THC in small quantities.

8. cbdMD CBD Oil Tincture Natural 750mg
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Vegan and Gluten free

Does not ship internationally

Has a third-party lab test

Wide variety of CBD strengths and sizes

Overview

A 750mg bottle of cbdMD’s Broad Spectrum Oil Tincture does not contain THC. It also has a fairly wide flavor range which is perfect for those who prefer other taste. Vegan consumers are considered since cbdMD offers Vegan products. Aside from all of that, another reason why people love cbdMD is because it’s free from harmful chemicals.

9. Hemp Bombs 750mg CBD Oil
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Wide variety of flavors

Incomplete information about the product

Lab test results are complete

Does not ship to all international countries

30-day money-back guarantee

Overview

Hemp Bombs offer CBD Oil Tinctures that come in a 30ml bottle containing 750mg of CBD. They provide a wide range of flavors perfect for those that have a knack for sweets. Consumers can safely intake this because it’s free of chemicals and pesticides. Hemp Bombs also offer a 20% off on products upon subscription.

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How CBD May Help With Overactive Bladder

The ECS ( endocannabinoid system) is present in almost all areas of the body (1) .

Evidence suggests that the components of the ECS, including anandamide and cannabinoid receptors, may be involved in bladder function regulation at several levels of the urination (micturition) pathway (2) .

Anandamide is an endogenous cannabinoid or endocannabinoid (3) . Research indicates that the body has receptors for the cannabinoids CB1 and CB2 in the brain, bladder, and other body parts (4) .

CB1, and to a lesser degree CB2, work at different levels on the detrusor muscles (5) . Studies suggest that CB1 receptors may affect urination, and their manipulation with cannabinoids from marijuana may help with overactive bladder (OAB) .

The detrusor muscle contracts during urination to push the urine out of the bladder and into the urethra (6) . When the detrusor muscle is relaxed, it allows the storage of urine in the urinary bladder .

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Individuals with OAB may experience urinary symptoms like sudden and frequent urination urges that are hard to control (7) .

While no conclusive data can validate CBD’s benefits for OAB, recent results are promising.

A 2020 study hypothesized that a sudden strong need to urinate that is difficult to delay may result from damage to a descending pathway that starts with the excitatory neurons in the prefrontal cortex (8) .

Meanwhile, research shows that CBD may act on targets throughout the brain, including the prefrontal cortex (9) . Hence, CBD may help individuals with OAB.

CBD, unlike THC (tetrahydrocannabinol), has a very low affinity for cannabinoid receptors (10) . Still, the activation of the cannabinoid receptors can help the detrusor muscles function properly (11) .

Like CBD , THC is a cannabinoid found in the cannabis plant (12) . THC is the predominant psychoactive constituent of cannabis (sometimes called marijuana) (13) .

A 2018 observational study hypothesized that THC-CBD oromucosal spray may effectively improve OAB symptoms in multiple sclerosis patients, demonstrating a favorable impact on detrusor overactivity (14) .

Multiple sclerosis or MS is a disabling illness of the central nervous system consisting of the brain and the spinal cord ( 15) . Urinary tract infections are often experienced by MS patients (16) .

However, some researchers believe that CBD may reduce the efficacy and potency of THC ( 17) .

Benefits of Using CBD for Overactive Bladder

Overactive bladder affects approximately 33 million people in the United States (18) . The condition is not an expected part of aging, contrary to what many people assume. OAB is an actual medical condition that needs treatment.

A pilot prospective study suggested that THC – CBD oromucosal spray may help improve overactive bladder symptoms in MS ( multiple sclerosis ) patients (19) .

Common symptoms of MS are problems with bladder function and spasticity , which causes the muscles to feel heavy and stiff.

A 2020 mini-review article published in the journal Frontiers in Physiology indicated that neural circuits extending from the cerebral cortex to the bladder avoid urinary incontinence (20) .

Urinary incontinence or leaking urine by accident is common among older people. Research suggests that one-fifth of individuals over 65 will lose some continence control (21) .

The authors of the 2020 mini-review hypothesized that a sudden strong need to urinate that is difficult to delay may result from damage to a descending pathway that starts with the excitatory neurons in the prefrontal cortex (22) .

The prefrontal cortex is the part of the brain covering the front part of the frontal lobe.

Although CBD has multiple targets, it may influence the activity of excitatory and inhibitory signaling pathways. CBD may act on targets throughout the brain, including the prefrontal cortex (23) .

OAB occurs when the nerve signals between the brain and the bladder do not work correctly (24) . Hence, using CBD may be beneficial for people with overactive bladder .

A review article from the University of Leicester stated that dysregulation of the ECS in the human bladder may be responsible for developing OAB and detrusor overactivity ( 25) .

The detrusor muscle is a smooth muscle found in the bladder. Detrusor overactivity refers to a urodynamic observation marked by involuntary detrusor contraction during the filling phase that may be spontaneous or provoked (26) .

A randomized controlled trial involving multiple sclerosis and neurogenic detrusor overactivity patients explored the effect of cannabinoids on reducing urge incontinence episodes without affecting voiding (27) .

About 630 patients were randomized to receive oral administration of the cannabis extract, THC , or matched placebo .

Based on incontinence diaries, there was a 25% reduction in the cannabis extract group. THC indicated a 19% reduction in urinary incontinence episodes relative to placebo .

The results suggested that cannabis may modulate detrusor function (28) .

Any incontinence may affect a person’s overall quality of life. An individual with OAB may also experience emotional distress, anxiety, sleep disturbances, and issues with sexuality (29) .

A 2019 Permanente Journal study suggested that CBD may hold benefits for anxiety-related disorders (30) .

The study consisted of 72 adults with anxiety concerns and poor sleep. About 57 patients reported reduced anxiety scores within the first month and remained decreased during the study duration.

Meanwhile, 48 patients reported improved sleep scores within the first month, although their scores fluctuated over time. CBD was also well tolerated in most participants, excluding three patients.

The results suggested that CBD has a calming effect and may hold benefits for anxiety-related disorders (31) .

While the results of these studies are promising, they are still inconclusive. Hence, further longitudinal research and more clinical trials are warranted to determine the possible benefits of CBD for overactive bladder .

How Long Does CBD Take to Help Overactive Bladder ?

CBD ’s efficacy depends on various factors, including individuals’ body weight, metabolism, CBD potency, and route of administration.

A study hypothesized that THC – CBD oromucosal spray may help with OAB symptoms in patients with multiple sclerosis (32) .

An oromucosal spray may be administered via the sublingual (under the tongue) route. CBD administered sublingually usually takes effect within 15 to 30 minutes (33) .

How Long Will CBD Help With Overactive Bladder ?

CBD is being pursued as a treatment option for several medical conditions , usually by oral delivery (34) .

A systematic search was conducted to retrieve all articles reporting the pharmacokinetic data of cannabidiol in humans (35) .

Out of the 792 articles retrieved, about 24 articles included pharmacokinetics parameters in humans.

The half-life of CBD was reported between 1.4 and 10.9 hours following oromucosal spray, two to five days after chronic oral administration, 24 hours after intravenous therapy (delivery of substances into the veins), and 31 hours after smoking (36) .

The bioavailability of CBD after smoking was 31% (37) .

Half-life is the length of time needed for the concentration of a specific drug to decrease by 50% of its starting dose in the body (38) .

Meanwhile, bioavailability refers to the extent to which a drug or substance becomes entirely available to its intended biological destination (39) .

The Possible Side Effects and Risks of Using CBD for Overactive Bladder

The Food and Drug Administration ( FDA) does not recognize CBD as a medical treatment for overactive bladder .

In addition, like other pharmaceutical drugs, alternative treatments, and supplements, CBD may also carry some risks and side effects .

The most commonly known side effects of CBD include (40) :

  • Dry mouth
  • Diarrhea
  • Reduced appetite
  • Drowsiness
  • Fatigue

Another cause for concern is a possible drug interaction. CBD, when taken with other drugs, may inhibit cytochrome P450 enzyme production at high doses (41) .

Cytochrome P450 enzymes are a family of liver enzymes that metabolize nearly 60% of the pharmaceutical drugs people consume (42) .

Tolterodine is used to treat overactive bladder . It is included in a class of medications called antimuscarinics that relax the bladder muscles (43) .

Tolterodine is also metabolized by cytochromes P450 (44) . Therefore, CBD may interact with tolterodine.

Legality of CBD

The United States Congress ratified the 2018 Farm Bill, decriminalizing the commercial use of industrial hemp and products obtained from hemp plants (45) .

The bill indicates that Cannabis sativa L. and other derivatives of cannabis with no more than 0.3% THC content on a dry weight basis are considered federally legal (46) .

The Federal Comprehensive Drug Abuse Prevention and Control Act of 1970 created a drug schedule to classify substances into five categories based on the potential for drug abuse and possible medical use of various substances (47) .

Some states have passed laws permitting recreational and medical marijuana . However, these state laws do not change the fact that, under federal law, marijuana is still listed as a Schedule I drug (48) .

Substances listed in the Schedule I drugs have a high abuse potential with no acceptable medical use (49) . Thus, medications under this category may not be dispensed, prescribed, or administered under federal law.

Rules and regulations regarding medical cannabis may be confusing. Therefore, consumers should familiarize themselves with various state laws.

Colorado is one of the states that legalized recreational and medical marijuana (50) .

Under HB 21-1317, Colorado limits the daily purchase of marijuana to two ounces of flower and eight grams of concentrates, like shatter and wax, for medical marijuana patients (51) .

The concentrate limit for medical patients between 18 and 20 is two grams per day (52) .

Exceptions to the limits apply to patients whose physicians confirm in writing that the patients have a physical hardship that should allow them to exceed their daily purchase limits (53) .

Product Frequently
Asked Questions

How can CBD help with overactive bladder?

A study suggested that THC – CBD oromucosal spray may help improve overactive bladder symptoms in MS ( multiple sclerosis ) patients (54) .

Another research indicated that the components of the endocannabinoid system may be involved in bladder function regulation at several levels of the urination pathway (55) .

CBD interacts with the endocannabinoid system, consisting of cannabinoid receptors (CB1 and CB2), enzymes, and cannabinoids (56) . The CB1 receptor is widely expressed throughout various peripheral tissues, including the urinary bladder (57) .

CBD may interact with cannabinoid receptors like CB1 at reasonably low concentrations (58) . CB1 plays a role in the pathophysiology of detrusor overactivity associated with bladder outlet obstruction (59) .

What evidence or research exists to say that CBD helps with overactive bladder?

There is limited evidence that suggests CBD helps with OAB ( overactive bladder ).

OAB causes frequent and sudden urination urges that may be hard to control. It occurs when the nerve signals between the brain and the bladder do not work correctly (60) .

A 2020 study hypothesized that a sudden strong need to urinate that is difficult to delay may result from damage to a descending pathway that starts with the excitatory neurons in the prefrontal cortex (61) .

CBD may act on targets throughout the brain, including the prefrontal cortex (62) . Hence, CBD may help people with overactive bladder .

Is there any evidence that CBD can make overactive bladder worse?

There is no evidence suggesting that CBD can make overactive bladder worse.

CBD is relatively safe and is generally well tolerated (63) . However, the compound may still carry risks and side effects such as dry mouth and fatigue (64) .

For this reason, ensure to consult your healthcare provider, especially if you are using CBD products like CBD oil for the first time to help with leakage or bladder control problems.

Will CBD interact with any current medication I may be taking for overactive bladder?

Yes, CBD may interact with any current medications you are taking for OAB .

The non-psychoactive compound may inhibit cytochrome P450 enzyme production at high doses (65) . The cytochrome P450 enzymes are vital for the metabolism of various medications.

Tolterodine, a medication used to treat OAB , is metabolized by cytochrome P450 enzymes (66) . Thus, CBD may interact with tolterodine.

Are there other treatments I should consider alongside CBD to help with overactive bladder?

Ensure to consult your physician first if you are considering other treatments or supplements alongside CBD .

They can advise you regarding risks, possible drug-to-drug interactions, and the best medication for OAB.

Medications for OA include tolterodine, which helps relax the bladder (67) .

In addition, your clinician may suggest behavioral therapies to manage an overactive bladder . Behavioral interventions often work and carry no side effects (68) .

Kegel exercise is a behavioral therapy that may help strengthen your pelvic floor muscles and urinary sphincter.

Meanwhile, bladder training involves training oneself to delay voiding once the urge to urinate is felt.

An individual with OAB may begin with slight delays like 30 minutes and then gradually work their way up to urinating every three to four hours (69) .

Meanwhile, studies show that gosha-jinki-gan (GJG), a traditional Chinese herbal medicine, may help with OAB (70) . However, most clinical trials were done on animal models.

Can I fail a drug test if I use CBD for an overactive bladder?

CBD is non-psychoactive (71) . Hence, it does not cause a euphoric high (72) .

Still, some CBD products like full-spectrum CBD oil have small amounts of THC . This psychoactive compound may build up in the body when taken regularly over as little as four to six days (73) .

An increased THC level in one’s bloodstream may result in a positive drug test.

What is the dosage for an overactive bladder?

The FDA does not recognize CBD as a medical treatment for overactive bladder . Therefore, there is no standard CBD dosage for OAB .

A study from Current Drug Safety stated that chronic use and high doses of CBD up to 1,500mg per day are well tolerated in humans (74) .

Meanwhile, mid-range doses of CBD between 10mg and 100mg per day have been shown to possibly help with pain management , anxiety, and multiple sclerosis (75) .

An individual with OAB may also experience anxiety (76) . Meanwhile, multiple sclerosis patients often experience overactive bladder symptoms (77 ) .

It is crucial to talk with your healthcare provider first if you are considering using CBD to manage OAB symptoms. They can recommend a proper CBD dosage for your condition.

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